Scientific Milestones Achieved To-Date
Featured Publications
Brain Tumors
2025
A multi-centre performance evaluation of a commercially developed liquid biopsy for the earlier detection of brain tumours
P M Brennan, J M Cameron, D Eustace, H J Butler, A Sala, A Lazarus, G Antoniou, D S Palmer, E Gray, C Kerrie, S McDonald, P Black, S Sheraz, I Adekoya, A Jakola, A Denes, M D Jenkinson, J Jones, S Pendered, S Koljenovic, K Zwaenepoel, A Sieben, M Ahmed, B Feyen, R K Mathew, C Coils, A Ismail, I Phang, A Brown, S Patel, T Weiss, P W Westarp, A Kopp, M J Baker
2024
Bioprocess monitoring applications of an innovative ATR-FTIR spectroscopy platform
Loren Christie, Samantha Rutherford, David S Palmer, Matthew J Baker, Holly J Butler
2023
A spectroscopic liquid biopsy for the earlier detection of multiple cancer types
JM Cameron, A Sala, G Antoniou, PM Brennan, HJB Butler, JJA Conn, S Connal, T Curran, MG Hegarty, RG Hardy, D Orringer, DS Palmer, BR Smith, MJ Baker
2023
Recurrent neural networks for time domain modelling of FTIR spectra: application to brain tumour detection
G Antoniou, JJA Conn, BR Smith, PM Brennan, MJ Bakr, DS Palmer
2022
Clinical Validation of a Spectroscopic Liquid Biopsy for Earlier Detection of Brain Cancer
JM Cameron, PM Brennan, G Antoniou, HJ Butler,…
Neurooncology Advances 4(1):vdac024
2021
Rapid Spectroscopic Liquid Biopsy for the Universal Detection of Brain Tumours
AG Theakstone, PM Brennan, MD Jenkinson,…
Cancers 13(15): 3851
2021
Early economic evaluation to guide the development of a spectroscopic liquid biopsy for the detection of brain cancer
E Gray, JM Cameron, HJ Butler, MD Jenkinson, MG Hegarty, DS Palmer, …
International Journal of Technology Assessment in Health Care 37
2021
Early diagnosis of brain tumours using a novel spectroscopic liquid biopsy
PM Brennan, HJ Butler, L Christie, MG Hegarty…Brain Communications
2020
Biofluid diagnostics by FTIR spectroscopy: A platform technology for cancer detection
A Sala, DJ Anderson, PM Brennan, HJ Butler, JM Cameron, …
Cancer letters 477, 122-130
2020
Stratifying brain tumour histological sub-types: the application of ATR-FTIR serum spectroscopy in secondary care
JM Cameron, C Rinaldi, HJ Butler, MG Hegarty, PM Brennan, …
Cancers 12 (7), 1710
2020
Interrogation of IDH1 status in gliomas by Fourier transform infrared spectroscopy
JM Cameron, JJA Conn, C Rinaldi, A Sala, PM Brennan, MD Jenkinson, …
Cancers 12 (12), 3682
2019
Development of high-throughput ATR-FTIR technology for rapid triage of brain cancer
HJ Butler, PM Brennan, JM Cameron, D Finlayson, MG Hegarty, …Nature Communications
2019
Developing IR spectroscopic detection for stratifying brain tumour patients
JM Cameron, HJ Butler, BR Smith, …
Analyst 144 (22), 6736-6750
2019
Development of high-throughput ATR-FTIR technology for rapid triage of brain cancer
HJ Butler, PM Brennan, JM Cameron, D Finlayson, MG Hegarty, …
Nature communications 10 (1), 1-9
2018
Health economic evaluation of a serum- based blood test for brain tumour diagnosis: exploration of two clinical scenarios
E Gray, HJ Butler, R Board, PM Brennan, AJ Chalmers, T Dawson, …
BMJ open 8 (5)
2016
Combining random forest and 2D correlation analysis to identify serum spectral signatures for neuro-oncology
BR Smith, KM Ashton, A Brodbelt, T Dawson, MD Jenkinson, NT Hunt, …
Analyst 141 (12), 3668-3678
2016
Brain tumour differentiation: rapid stratified serum diagnostics via ATR-FTIR spectroscopy
JR Hands, G Clemens, R Stables, K Ashton, A Brodbelt, C Davis, …
Journal of neuro-oncology 127 (3), 463-472
2014
Attenuated total reflection Fourier transform infrared (ATR‐FTIR) spectral discrimination of brain tumour severity from serum samples
JR Hands, KM Dorling, P Abel, KM Ashton, A Brodbelt, C Davis, …
Journal of biophotonics 7 (3‐4), 189-199
2013
Investigating the rapid diagnosis of gliomas from serum samples using infrared spectroscopy and cytokine and angiogenesis factors
JR Hands, P Abel, K Ashton, T Dawson, C Davis, RW Lea, AJS McIntosh, …
Analytical and bioanalytical chemistry 405 (23), 7347-7355
2025
Colorectal cancer molecular profiling: Opportunities for early detection
Alexandra Sala, Lisa van den Driest, Nicholas J. W. Rattray, Caroline H. Johnson, James M. Cameron, Sajid A. Khan, David S. Palmer, Matthew J. Baker
2025
A Multi-omic Liquid Biopsy for Early Colorectal Cancer Detection
Holly Butler, James M. Cameron, Rose G. McHardy, Alexandra Sala, David S. Palmer, Peter Mitchell,, Edward Parkin, Susan Moug, and Matthew J. Baker
2025
A Multi-omic Liquid Biopsy for the Earlier Detection of Pancreatic Cancer
Holly Butler, James M. Cameron, David S. Palmer, and Matthew J. Baker
2025
Early Detection of Pancreatic Cancer with a Multi-omic Liquid Biopsy
Holly Butler, James M. Cameron, Alexandra Sala, David S. Palmer, and Matthew J. Baker
2024
Augmentation of FTIR spectral datasets using Wasserstein generative adversarial networks for cancer liquid biopsies
RG Hardy, G Antoniou, JJA Conn, MJ Baker, DS Palmer
2022
Liquid Biopsy for Pancreatic Cancer Detection Using Infrared Spectroscopy
Alexandra Sala, James M Cameron, Cerys A Jenkins, Hugh Barr, Loren Christie, Justin J A Conn, Thomas R Jeffry Evans, Dean A Harris, David S Palmer, Christopher Rinaldi, Ashton G Theakstone, Matthew J Baker
2023
A spectroscopic liquid biopsy for the earlier detection of multiple cancer types
JM Cameron, A Sala, G Antoniou, PM Brennan, HJ Butler, JJA Conn, S Connal, T Curran, MG Hegarty, RG Hardy, D Orringer, DS Palmer, BR Smith, MJ Baker
2023
Liquid biopsies: the future of cancer early detection
S Connal, JM Cameron, A Sala, PM Brennan, DS Palmer, JD Palmer, H Perlow, MJ Baker
2023
Global serum profiling: an opportunity for earlier cancer detection
A Sala, JM Cameron, PM Brennan, EJ Crosbie, T Curran, E Gray, P artin-Hirsch, IU Rehman, NJW Rattray, MJ Baker
2021
Clinical Spectroscopy: Lost in Translation?
JM Cameron, C Rinaldi, SH Rutherford, A Sala,…
Applied Spectroscopy
2020
Shining a light on clinical spectroscopy: Translation of diagnostic IR, 2D-IR and Raman spectroscopy towards the clinic
HJ Butler, JM Cameron, CA Jenkins, G Hithell, S Hume, NT Hunt, …
Clinical Spectroscopy 1, 100003
2020
Vibrational spectroscopic analysis and quantification of proteins in human blood plasma and serum
JM Cameron, C Bruno, DR Parachalil, MJ Baker, F Bonnier, HJ Butler, …
Vibrational Spectroscopy in Protein Research, 269-314
2020
Biofluid diagnostics by FTIR spectroscopy: A platform technology for cancer detection
A Sala, DJ Anderson, PM Brennan, HJ Butler, JM Cameron, …
Cancer letters 477, 122-130
2020
Liquid biopsy for cancer diagnosis using vibrational spectroscopy: systematic review
DJ Anderson, RG Anderson, SJ Moug, MJ Baker
BJS open 4 (4), 554
2019
Is infrared spectroscopy ready for the clinic?
D Finlayson, C Rinaldi, MJ Baker
Analytical chemistry 91 (19), 12117-12128
2016
A review of novel analytical diagnostics for liquid biopsies: spectroscopic and spectrometric serum profiling of brain tumors
K Spalding, R Board, T Dawson, MD Jenkinson, MJ Baker
Brain and behavior 6 (9), e00502
2013
Highlighting attenuated total reflection Fourier transform infrared spectroscopy for rapid serum analysis
KM Dorling, MJ Baker
Trends in biotechnology 31 (6), 327-328
2025
From Lab to Clinic: Artificial Intelligence with Spectroscopic Liquid Biopsies
Rose G. McHardy, James M. Cameron, David Andrew Eustace, Matthew J. Baker, and David S. Palmer
2021
Fourier-transform infrared spectroscopy of biofluids: A practical approach
Ashton G. Theakstone, Christopher Rinaldi, Holly J. Butler, James M. Cameron, Lily Rose Confield, Samantha H. Rutherford, Alexandra Sala, Sayali Sangamnerkar, Matthew J. Baker
2024
Process monitoring applications of an innovative ATR-FTIR spectroscopy
L Christie, S Rutherford, BR Smith, DS Palmer, MJ Baker, HJ Butler
2023
Rapid detection of heat failure using a spectroscopic liquid biopsy
L Christie, A Sala, JM Cameron, JJA Conn, DS Palmer, WJ McGeown, JA Cannon, J Sharp, MJ Baker
2020
Exploring pre analytical factors for the optimisation of serum diagnostics: Progressing the clinical utility of ATR-FTIR spectroscopy
JM Cameron, HJ Butler, DJ Anderson, L Christie, L Confield, KE Spalding, …
Vibrational Spectroscopy 109, 103092
2020
Rapid analysis of disease state in liquid human serum combining infrared spectroscopy and “digital drying”
A Sala, KE Spalding, KM Ashton, R Board, HJ Butler, TP Dawson, …
Journal of Biophotonics 13 (9), e202000118
2019
Investigating pre‐ analytical requirements for serum and plasma based infrared spectro‐diagnostic
L Lovergne, J Lovergne, P Bouzy, V Untereiner, M Offroy, R Garnotel, …
Journal of biophotonics 12 (12), e20190017
2018
Optimised spectral pre-processing for discrimination of biofluids via ATR-FTIR spectroscopy
HJ Butler, BR Smith, R Fritzsch, P Radhakrishnan, DS Palmer, MJ Baker
Analyst 143 (24), 6121-6134
2018
Biofluid spectroscopic disease diagnostics: A review on the processes and spectral impact of drying
JM Cameron, HJ Butler, DS Palmer, MJ Baker
Journal of biophotonics 11 (4), e201700299
2016
Biofluid infrared spectro-diagnostics: pre-analytical considerations for clinical applications
L Lovergne, P Bouzy, V Untereiner, R Garnotel, MJ Baker, G Thiéfin, …
Faraday discussions 187, 521-537
2015
Investigating optimum sample preparation for infrared spectroscopic serum diagnostics
L Lovergne, G Clemens, V Untereiner, RA Lukaszweski, GD Sockalingum, …
Analytical Methods 7 (17), 7140-7149
2014
Using Fourier transform IR spectroscopy to analyze biological materials
MJ Baker, J Trevisan, P Bassan, R Bhargava, HJ Butler, KM Dorling, …
Nature protocols 9 (8), 1771
All Publications
2023
2025
A multi-centre performance evaluation of a commercially developed liquid biopsy for the earlier detection of brain tumours
P M Brennan, J M Cameron, D Eustace, H J Butler, A Sala, A Lazarus, G Antoniou, D S Palmer, E Gray, C Kerrie, S McDonald, P Black, S Sheraz, I Adekoya, A Jakola, A Denes, M D Jenkinson, J Jones, S Pendered, S Koljenovic, K Zwaenepoel, A Sieben, M Ahmed, B Feyen, R K Mathew, C Coils, A Ismail, I Phang, A Brown, S Patel, T Weiss, P W Westarp, A Kopp, M J Baker
2025
Colorectal cancer molecular profiling: Opportunities for early detection
Alexandra Sala, Lisa van den Driest, Nicholas J. W. Rattray, Caroline H. Johnson, James M. Cameron, Sajid A. Khan, David S. Palmer, Matthew J. Baker
2025
A Multi-omic Liquid Biopsy for Early Colorectal Cancer Detection
Holly Butler, James M. Cameron, Rose G. McHardy, Alexandra Sala, David S. Palmer, Peter Mitchell,, Edward Parkin, Susan Moug, and Matthew J. Baker
2025
A Multi-omic Liquid Biopsy for the Earlier Detection of Pancreatic Cancer
Holly Butler, James M. Cameron, David S. Palmer, and Matthew J. Baker
2025
Early Detection of Pancreatic Cancer with a Multi-omic Liquid Biopsy
Holly Butler, James M. Cameron, Alexandra Sala, David S. Palmer, and Matthew J. Baker
2025
From Lab to Clinic: Artificial Intelligence with Spectroscopic Liquid Biopsies
Rose G. McHardy, James M. Cameron, David Andrew Eustace, Matthew J. Baker, and David S. Palmer
2024
Bioprocess monitoring applications of an innovative ATR-FTIR spectroscopy platform
Loren Christie, Samantha Rutherford, David S Palmer, Matthew J Baker, Holly J Butler
2023
A spectroscopic liquid biopsy for the earlier detection of multiple cancer types
JM Cameron, A Sala, G Antoniou, PM Brennan, HJB Butler, JJA Conn, S Connal, T Curran, MG Hegarty, RG Hardy, D Orringer, DS Palmer, BR Smith, MJ Baker
2023
Global serum profiling: an opportunity for earlier cancer detection
A Sala, JM Cameron, PM Brennan, EJ Crosbie, T Curran, E Gray, P artin-Hirsch, IU Rehman, NJW Rattray, MJ Baker
2023
Recurrent neural networks for time domain modelling of FTIR spectra: application to brain tumor detection
G Antoniou, JJA Conn, BR Smith, PM Brennan, MJ Bakr, DS Palmer
2023
Liquid biopsies: the future of cancer early detection
S Connal, JM Cameron, A Sala, PM Brennan, DS Palmer, JD Palmer, H Perlow, MJ Baker
2023
Augmentation of FTIR spectral datasets using Wasserstein generative adversarial networks for cancer liquid biopsies
RG Hardy, G Antoniou, JJA Conn, MJ Baker, DS Palmer
2022
Clinical Validation of a Spectroscopic Liquid Biopsy for Earlier Detection of Brain Cancer
JM Cameron, PM Brennan, G Antoniou, HJ Butler,…
Neurooncology Advances 4(1):vdac024
2022
Liquid Biopsy for Pancreatic Cancer Detection Using Infrared Spectroscopy
Alexandra Sala, James M Cameron, Cerys A Jenkins, Hugh Barr, Loren Christie, Justin J A Conn, Thomas R Jeffry Evans, Dean A Harris, David S Palmer, Christopher Rinaldi, Ashton G Theakstone, Matthew J Baker
2021
Rapid Spectroscopic Liquid Biopsy for the Universal Detection of Brain Tumours
AG Theakstone, PM Brennan, MD Jenkinson,…
Cancers 13(15): 3851
2021
Early economic evaluation to guide the development of a spectroscopic liquid biopsy for the detection of brain cancer
E Gray, JM Cameron, HJ Butler, MD Jenkinson, MG Hegarty, DS Palmer, …
International Journal of Technology Assessment in Health Care 37
2021
Clinical Spectroscopy: Lost in Translation?
JM Cameron, C Rinaldi, SH Rutherford, A Sala,…
Applied Spectroscopy
2021
Fourier-transform infrared spectroscopy of biofluids: A practical approach
Ashton G. Theakstone, Christopher Rinaldi, Holly J. Butler, James M. Cameron, Lily Rose Confield, Samantha H. Rutherford, Alexandra Sala, Sayali Sangamnerkar, Matthew J. Baker
2020
Interrogation of IDH1 status in gliomas by Fourier transform infrared spectroscopy
JM Cameron, JJA Conn, C Rinaldi, A Sala, PM Brennan, MD Jenkinson, …
Cancers 12 (12), 3682
2020
Stratifying brain tumour histological sub-types: the application of ATR-FTIR serum spectroscopy in secondary care
JM Cameron, C Rinaldi, HJ Butler, MG Hegarty, PM Brennan, …
Cancers 12 (7), 1710
2020
Rapid analysis of disease state in liquid human serum combining infrared spectroscopy and “digital drying”
A Sala, KE Spalding, KM Ashton, R Board, HJ Butler, TP Dawson, …
Journal of Biophotonics 13 (9), e202000118
2020
Liquid biopsy for cancer diagnosis using vibrational spectroscopy: systematic review
DJ Anderson, RG Anderson, SJ Moug, MJ Baker
BJS open 4 (4), 554
2020
Exploring pre analytical factors for the optimisation of serum diagnostics: Progressing the clinical utility of ATR-FTIR spectroscopy
JM Cameron, HJ Butler, DJ Anderson, L Christie, L Confield, KE Spalding, …
Vibrational Spectroscopy 109, 103092
2020
Biofluid diagnostics by FTIR spectroscopy: A platform technology for cancer detection
A Sala, DJ Anderson, PM Brennan, HJ Butler, JM Cameron, …
Cancer letters 477, 122-130
2020
Liquid biopsy for cancer diagnosis using vibrational spectroscopy: systematic review
JM Cameron, C Bruno, DR Parachalil, MJ Baker, F Bonnier, HJ Butler, …
Vibrational Spectroscopy in Protein Research, 269-314
2020
Shining a light on clinical spectroscopy: Translation of diagnostic IR, 2D-IR and Raman spectroscopy towards the clinic
HJ Butler, JM Cameron, CA Jenkins, G Hithell, S Hume, NT Hunt, …
Clinical Spectroscopy 1, 100003
2019
Development of high-throughput ATR-FTIR technology for rapid triage of brain cancer
HJ Butler, PM Brennan, JM Cameron, D Finlayson, MG Hegarty, …
Nature communications 10 (1), 1-9
2019
Developing IR spectroscopic detection for stratifying brain tumour patients
JM Cameron, HJ Butler, BR Smith, …
Analyst 144 (22), 6736-6750
2019
Is infrared spectroscopy ready for the clinic?
D Finlayson, C Rinaldi, MJ Baker
Analytical chemistry 91 (19), 12117-12128
2019
Investigating pre‐ analytical requirements for serum and plasma based infrared spectro‐diagnostic
L Lovergne, J Lovergne, P Bouzy, V Untereiner, M Offroy, R Garnotel, …
Journal of biophotonics 12 (12), e20190017
2018
Health economic evaluation of a serum- based blood test for brain tumour diagnosis: exploration of two clinical scenarios
E Gray, HJ Butler, R Board, PM Brennan, AJ Chalmers, T Dawson, …
BMJ open 8 (5)
2018
Optimised spectral pre-processing for discrimination of biofluids via ATR-FTIR spectroscopy
HJ Butler, BR Smith, R Fritzsch, P Radhakrishnan, DS Palmer, MJ Baker
Analyst 143 (24), 6121-6134
2018
Biofluid spectroscopic disease diagnostics: A review on the processes and spectral impact of drying
JM Cameron, HJ Butler, DS Palmer, MJ Baker
Journal of biophotonics 11 (4), e201700299
2016
A review of novel analytical diagnostics for liquid biopsies: spectroscopic and spectrometric serum profiling of brain tumors
K Spalding, R Board, T Dawson, MD Jenkinson, MJ Baker
Brain and behavior 6 (9), e00502
2016
Biofluid infrared spectro-diagnostics: pre-analytical considerations for clinical applications
L Lovergne, P Bouzy, V Untereiner, R Garnotel, MJ Baker, G Thiéfin, …
Faraday discussions 187, 521-537
2016
Combining random forest and 2D correlation analysis to identify serum spectral signatures for neuro-oncology
BR Smith, KM Ashton, A Brodbelt, T Dawson, MD Jenkinson, NT Hunt, …
Analyst 141 (12), 3668-3678
2016
Brain tumour differentiation: rapid stratified serum diagnostics via ATR-FTIR spectroscopy
JR Hands, G Clemens, R Stables, K Ashton, A Brodbelt, C Davis, …
Journal of neuro-oncology 127 (3), 463-472
2015
Investigating optimum sample preparation for infrared spectroscopic serum diagnostics
L Lovergne, G Clemens, V Untereiner, RA Lukaszweski, GD Sockalingum, …
Analytical Methods 7 (17), 7140-7149
2014
Attenuated total reflection Fourier transform infrared (ATR‐FTIR) spectral discrimination of brain tumour severity from serum samples
JR Hands, KM Dorling, P Abel, KM Ashton, A Brodbelt, C Davis, …
Journal of biophotonics 7 (3‐4), 189-199
2014
Using Fourier transform IR spectroscopy to analyze biological materials
MJ Baker, J Trevisan, P Bassan, R Bhargava, HJ Butler, KM Dorling, …
Nature protocols 9 (8), 1771
2013
Highlighting attenuated total reflection Fourier transform infrared spectroscopy for rapid serum analysis
KM Dorling, MJ Baker
Trends in biotechnology 31 (6), 327-328